Download Aquaporins by Jennifer M. Carbrey, Peter Agre (auth.), Prof. Dr. Eric PDF

By Jennifer M. Carbrey, Peter Agre (auth.), Prof. Dr. Eric Beitz (eds.)

The aquaporin box has matured at an extremely speedy velocity and we're on the verge to boost severe techniques to therapeutically modulate aquaporin functionality without delay or through regulatory networks. Key necessities can be found this present day: i. a substantial (and starting to be) variety of aquaporin crystal buildings for the rational layout of inhibitory molecules, ii. intricate molecular dynamics simulation options for theoretical analyses of selectivity mechanisms and docking experiments, iii. complete information on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological stories, and v. assay structures for compound library screenings. The constitution of this quantity on aquaporins follows the issues laid out above and hence covers the advancements from simple learn to power pharmacological use. positioned among pharmacology textbooks and up to date medical papers this ebook presents a well timed evaluate for readers from the elemental in addition to the utilized disciplines.

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3 Anion Transport . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Gas Transport . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 33 36 37 38 38 41 45 45 48 49 50 51 51 Abstract Progress in the structure determination of AQPs has led to a deep understanding of water and solute permeation by these small integral membrane proteins.

1 The AQP Fold . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 The Structure of the Pore . . . . . . . . . . . . . . . . . . . . . . . . 3 Surface Structure of AQPs Involved in Membrane Junctions . . . . . . . . . 4 Unsolved Riddles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 AQP Trafficking . . . . . . . . . . . . . . . . . . .

References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 33 36 37 38 38 41 45 45 48 49 50 51 51 Abstract Progress in the structure determination of AQPs has led to a deep understanding of water and solute permeation by these small integral membrane proteins. The atomic structures now available have allowed the water permeation and exclusion of protons to be monitored by molecular dynamics simulations, and have provided a framework for assessing the water and solute permeation in great detail by site-directed mutations.

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